Medication Safety Issues
Sound-alike/look-alike issues:
Yaz may be confused with Beyaz, Yasmin
Storage/Stability
Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F).
Adverse Reactions
- Frequency not defined. Reactions listed are based on reports for other agents in this same pharmacologic class (oral contraceptives) and may not be specifically reported for drospirenone/ethinyl estradiol.
- Increased risk or evidence of association with use:
- Cardiovascular: Arterial thromboembolism, cerebral thrombosis, hypertension, local thrombophlebitis, mesenteric thrombosis, myocardial infarction, pulmonary embolism, retinal thrombosis
- Central nervous system: Cerebral hemorrhage
- Gastrointestinal: Gallbladder disease
- Hepatic: Hepatic adenoma, hepatic neoplasm (benign)
Adverse reactions considered drug related:
- Cardiovascular: Edema, worsening of varicose veins
- Central nervous system: Depression, exacerbation of tics, migraine
- Dermatologic: Allergic skin rash, chloasma
- Endocrine & metabolic: Amenorrhea, breast changes (breast hypertrophy, breast secretion, breast tenderness, mastalgia), decreased serum folate level, exacerbation of porphyria, menstrual disease (menstrual flow changes), weight changes
- Gastrointestinal: Abdominal cramps, bloating, carbohydrate intolerance, nausea, vomiting
- Genitourinary: Breakthrough bleeding, cervical ectropion, cervical erosion, change in cervical secretions, decreased lactation (with use immediately postpartum), infertility (temporary), spotting, vulvovaginal candidiasis
- Hepatic: Cholestatic jaundice
- Hypersensitivity: Anaphylaxis/anaphylactoid reaction (including angioedema, circulatory shock, respiratory collapse, urticaria)
- Neuromuscular & skeletal: Exacerbation of systemic lupus erythematosus
- Ophthalmic: Change in corneal curvature (steepening), contact lens intolerance
Adverse reactions in which association is not confirmed or denied:
- Cardiovascular: Budd-Chiari syndrome
- Central nervous system: Dizziness, headache, nervousness
- Dermatologic: Acne vulgaris, erythema multiforme, erythema nodosum, loss of scalp hair
- Endocrine & metabolic: Change in libido, hirsutism, porphyria, premenstrual syndrome
- Gastrointestinal: Change in appetite, colitis, pancreatitis
- Genitourinary: Cystitis-like syndrome, dysmenorrhea, vaginitis
- Hematologic & oncologic: Hemolytic-uremic syndrome, hemorrhagic eruption
- Ophthalmic: Cataract, optic neuritis (with or without partial or complete loss of vision)
- Renal: Renal insufficiency
