Storage/Stability
Store at 25°C (77°F); excursions are permitted between 15°C and 30°C (59°F and 86°F).
Adverse Reactions
>10%:
Central nervous system: Fatigue (26%), headache (22%), dizziness (18%)
Dermatologic: Skin rash (30%)
Gastrointestinal: Nausea (36%), diarrhea (26%), abdominal pain (24%), dyspepsia (19%), anorexia (13%), vomiting (13%), gastroesophageal reflux disease (11%)
Respiratory: Upper respiratory tract infection (27%), sinusitis (11%)
1% to 10%:
Central nervous system: Insomnia (10%), noncardiac chest pain (5%)
Dermatologic: Skin photosensitivity (9%), pruritus (8%)
Endocrine & metabolic: Weight loss (10%)
Gastrointestinal: Decreased appetite (8%), dysgeusia (6%)
Hepatic: Increased serum transaminases (ALT and AST; ≥3 x ULN: 4%)
Neuromuscular & skeletal: Arthralgia (10%), asthenia (6%)
Postmarketing: Agranulocytosis, angioedema, hepatotoxicity
