Gluconorm G1 (Amaryl M)1/500 Mg – 150 tablet


Each Gluconorm contains Glimepride and Metformin 150 tablets. Is an oral medication used to control blood sugar control in type 2 diabetes

Active Ingrediant: Glimepiride and Metformin
Generic Name: Gluconorm G1
Manufacturer: Lupin Pharma
Strength: 1/500 Mg
Dosage Type: Tablet
Packaging Type: Foil in Box
Contains: 150 Tab

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Glimepiride and Metformin Information

What is the drug use for?

  • It is used to treat type 2 diabetes mellitus when diet, physical exercise and weight reduction alone have not been able to control your blood sugar levels

Possible side effects

Glimepiride and Metformin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • Diarrhea
  • Nausea
  • Upset stomach

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

  • Allergic reactions (including inflammation of blood vessels, often with skin rash) which may develop into serious reactions with difficulty in breathing, fall in blood pressure and sometimes progressing to shock
  • Abnormal liver function including yellowing of the skin and eyes (jaundice), problems with the bile flow (cholestasis), inflammation of the liver (hepatitis) or liver failure
  • Allergy (hypersensitivity) of the skin such as itching, rash, hives and increased sensitivity to sun
  • Severe hypoglycaemia including loss of consciousness, seizures or coma

Medication Safety Issues

International issues:

Amaryl M may be confused with Amaryl brand name for glimepiride [multiple international markets], Amarel brand for glimepiride [France].

High alert medication:

The Institute for Safe Medication Practices (ISMP) includes glimepiride among its list of drugs which have a heightened risk of causing significant patient harm when used in error.

Geriatric Patients: High-Risk Medication:

Beers Criteria: Glimepiride is identified in the Beers Criteria as a potentially inappropriate medication to be avoided in patients ≥65 years (independent of diagnosis or condition) due to higher risk of severe prolonged hypoglycemia in older adults (Beers Criteria [AGS 2019]).

Product Availability

Not available in the US

Storage and Stability

Store below 30ºC (≤86ºF).

Adverse Reactions

Also see individual agents.

>10%: Endocrine & metabolic: Hypoglycemia (32% to 43%), hypoglycemia signs and symptoms (32% to 39%; severe hypoglycemia [night hypoglycemia events: 1% to 5%])

1% to 10%:

Gastrointestinal: Epigastric pain (2% to 4%), abdominal distress (1%), abnormal bowel sounds (1%), constipation (1%)
Hematologic & oncologic: Thrombocytopenia (1%)
Frequency not defined:
Endocrine & metabolic: Lactic acidosis
Hypersensitivity: Hypersensitivity reaction

<1%, postmarketing, and/or case reports: Abdominal distention, abdominal pain, benign prostatic hypertrophy, carcinoma (rectum), diarrhea, dizziness, dyspepsia, flushing, hyperkalemia, hypertension, lower extremity edema, nausea, pain, palpitations, swelling of extremities, vomiting