Pentosan Polysulfate Sodium Information
What is this drug used for?
• It is used to ease pain, swelling, and irritation of the bladder.
Possible side effects
Pentosan Polysulfate Sodium may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
• Diarrhea.
• Upset stomach.
• Headache.
• Hair loss.
• Dizziness.
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:
• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Signs of bleeding like throwing up or coughing up blood; vomit that looks like coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; abnormal vaginal bleeding; bruises without a cause or that get bigger; or bleeding you cannot stop.
• Weight gain.
• Swelling.
Medication Safety Issues
Sound-alike/look-alike issues:
Pentosan may be confused with pentostatin
Elmiron may be confused with Imuran
Storage and Stability
Store at room temperature of 15°C to 30°C (59°F to 86°F).
Adverse Reactions
1% to 10%:
Central nervous system: Headache (3%), dizziness (1%)
Dermatologic: Alopecia (4%), skin rash (3%)
Gastrointestinal: Diarrhea (4%), nausea (4%), abdominal pain (2%), dyspepsia (2%)
Hematologic & oncologic: Rectal hemorrhage (6%)
Hepatic: Abnormal hepatic function tests (1%; dose-related)
<1%, postmarketing, and/or case reports: Amblyopia, anemia, anorexia, colitis, conjunctivitis, constipation, dehydration, depression, diaphoresis, dyspnea, ecchymoses, emotional lability, epistaxis, esophagitis, flatulence, gastritis, gingival hemorrhage, hyperkinetic muscle activity, hypersensitivity reaction, insomnia, leukopenia, maculopathy (Hanif 2019), optic neuritis, oral mucosa ulcer, pharyngitis, prolonged partial thromboplastin time, prolonged prothrombin time, pruritus, retinal hemorrhage, rhinitis, skin photosensitivity, thrombocytopenia, tinnitus, urticaria, vomiting
